Microglia and Neuronal Degeneration

Microglia in Neuronal Circuits

1 Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA 2Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA 3Department of Neurobiology, Zhejiang University School of Medicine, 866 Yu Hang Tang Road, Hangzhou, Zhejiang 310058, China 4Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vanc...

Microglia and interleukin-1β in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A.

OBJECTIVE Proinflammatory cytokines contribute to the development of retinal vasculopathies. However, the role of these factors and the mechanisms by which they elicit their effects in retina are not known. We investigated whether activated microglia during early stages of ischemic retinopathy produces excessive interleukin-1β (IL-1β), which elicits retinal microvascular degeneration not direct...

Diabetes Mellitus Type1 and Neuronal Degeneration in Ventral and Dorsal Hippocampus

  Background and Objectives: Studies have documented the morhplogical, neurochemical and functional difference between the dorsal and ventral zones of hippocampus. The aim of this study was to assess the effects of chronic diabetes mellitus type1 on ventral and dorsal zones of hippocampus. Methods: Experimental diabetes was induced by stereptozotocin at a dose of 60 mg/kg. At the end of 8 wee...

Neuronal degeneration and mitochondrial dysfunction.

Activation of microglia and chemokines in light-induced retinal degeneration.

PURPOSE Microglial cells, which are activated and recruited by chemokines, have been shown to play crucial roles in neuronal degenerations of the central nervous system (CNS). This study investigated the activation and migration of retinal microglial cells and expression of chemokines in retinas in light-induced photoreceptor degeneration in mice. METHODS Ninety-five Balb/cJ mice were kept in...